Lock Angus Blyth has been ruled out with a minor shoulder injury, meaning Angus Scott-Young slots into the second-row in his first Super Rugby AU start.
Following a man-of-the-match performance against the Rebels, Chris Feauai-Sautia also comes into the starting side this week on the wing, as Jock Campbell shifts to fullback.
There are a further four changes to the bench with front-rower Jack Straker and lock Ryan Smith set to potentially make their Super Rugby and Reds debuts.
Meanwhile, prop Dane Zander and outside back Bryce Hegarty have both been named as finishers for this fixture.
Thorn said: "It's good to be back home this week.
"We've dug deep and come away with points in our last couple of games. We're building our game and looking for improvement on Friday night.
"It's great to have the Force back in the competition. They were competitive against the Waratahs in their first hit-out. They've got plenty of experience with a few Queenslanders there too. We're expecting them to be a tough opponent.
"Jack Straker and Ryan Smith have been named in the 23 and could make their debuts. They've worked hard in our program and deserve their selection," said Thorn.
The Reds have their first bye of the new tournament next week before travelling to Canberra in Round 5 against the Brumbies.
15 Jock Campbell, 14 Chris Feauai-Sautia, 13 Hunter Paisami, 12 Hamish Stewart, 11 Filipo Daugunu, 10 James O'Connor, 9 Tate McDermott, 8 Harry Wilson, 7 Fraser McReight, 6 Liam Wright (captain), 5 Lukhan Salakaia-Loto, 4 Angus Scott-Young, 3 Taniela Tupou, 2 Brandon Paenga-Amosa, 1 Harry Hoopert
Substitutes: 16 Alex Mafi, 17 Dane Zander, 18 Jack Straker, 19 Ryan Smith, 20 Tuaina Taii Tualima, 21 Scott Malolua, 22 Josh Flook, 23 Bryce Hegarty
15 Jack McGregor, 14 Byron Ralston, 13 Marcel Brache, 12 Nick Jooste, 11 Brad Lacey, 10 Jono Lance, 9 Ian Prior, 8 Brynard Stander, 7 Tevin Ferris, 6 Henry Stowers, 5 Fergus Lee Warner, 4 Jeremy Thrush, 3 Kieran Longbottom, 2 Feleti Kaitu'u, 1 Angus Wagner.
Substitutes: 16 Andrew Ready, 17 Chris Heiberg, 18 Greg Holmes, 19 Ollie Atkins 20 Ollie Callan, 21 Jacob Abel, 22 Henry Taefy, 23 Kyle Godwin
- TEAMtalk media